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Molecular features:
Main distribution/differences
gastric adenocarcinoma:
1) Chromosomal instable (CIS) 49,8%
2) Microsatellite-instable (MSI) 21,7%
3) Genomic stable (GS) 19,6%
4) EBV-induced (EBV) 8,9
%
Institute of Pathology | Alexander Quaas
Gastrointestinal Cancer Group Cologne (GCGC)
From: Cancer Genome Atlas Research Network Group:
1) Integrated molecular characterization of esophageal carcinoma, Nature 2017
2) Epstein-Barr Virus Infection and Mismatch Repair Deficiency in Esophageal Cancer: Clinical Implication for Potential Treatment with
PD1/PD-L1 Blockade Therapy;
L.C. Hewitt, I.Z Inam, A. Quaas…. and H.Grabsch
esophageal adenocarcinoma:
1) EAC = CIS
ERBB2 amplification
(like in gastric carcinoma)
2) MSI and EBV very rare