Microsoft PowerPoint - 17 Introduction Valentini [Compatibil

Introduction

• More than 50% of patients have inoperable disease at presentation

• Around 35% of patients with EC present with metastatic disease

• These patients have an extremely poor prognosis:

• 1-yr survival rate 18%

• Median survival 3-5 months

• In 80-90% of LA-EC dysphagia is predominant symptom

• There are different modalities to achieve adequate locoregional palliation:

• EBRT

• Brachytherapy

• Chemoradiotherapy

• Chemotherapy

• Endoscopic stent placement

• There is no consensus on which regimen should be used in first line