480 / 1084
Brachy w/wo EBRT
N=219
65% St IIA
80% distal
SCC
Tumor length
6.7 cm
HDR-BT (N=109)
2x8 Gy (<1 wk)
Primary endpoint: Dysphagia Relief Experience
HDR-BT + EBRT (N=110)
2x8 Gy + 10x3 Gy
R
•
Symptom improvement occurs when EBRT is added to HDR-BT
•
Combined treatment is well tolerated and relatively safe (similar OS)
Rosenblatt et al. R&O 2010
HDR-BT
HDR-BT + EBRT
Dysphagia score
Time from randomization (wks)