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Adjuvant chemotherapy was associated with a

statistically significant benefit in terms of overall

survival

(hazard ratio [HR], 0.82; 95% confidence interval

[CI], 0.76-0.90;

P

.001)

The estimated

median OS was 4.9 years

(95% CI, 4.4-

5.5)

in the surgery-only group

vs

7.8 years

(95% CI,

6.5-8.7) in the group receiving

adjuvant chemotherapy

Absolute benefits

were

5.8% at 5 years

(from 49.6%

to 55.3%) and

7.4% at 10 years

(from 37.5% to 44.9%)

03/27/2017