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POLE-mutated gastric
carcinoma about 5%
Institute of Pathology | Alexander Quaas
Gastrointestinal Cancer Group Cologne (GCGC)
From: Church, DN Prognostic significance of POLE proofreading mutations in endometrial cancer, J Natl Cancer Inst 2015
Stenzinger A Mutations in POLE and survival of colorectal cancer patients – link to disease stage and treatment, Cancer Med. 2014
- G3 morphology?
- Good prognosis?
- Highly sensitive to chemotherapy?