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Kidney
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Radiation-induced renal dysfunction:
•
wide array of endpoints (creatinine clearance to renal failure)
•
Bilateral
whole kidney
irradiation: pooled analysis by Cassady:
•
mean dose of 18 Gy corresponded to a 5% risk of injury at 5 years.
•
For bilateral
partial kidney
irradiation, the data is less clear
•
Small volumes of the kidney can tolerate relatively high doses of radiation
QUANTEC:
•
<5% risk of injury when the mean kidney dose is limited to <18 Gy.
•
Current common practice of limiting the equivalent of one kidney to <20 Gy
Cassady JR. Clinical radiation nephropathy. Int J Radiat Oncol Biol Phys 1995;31:1249–1256