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The accurate classification of MSI-GC may become clinically relevant for two reasons:

(1) MSI-GCs may not require

any standard adjuvant (radio-)chemotherapy

in a

curative setting;

(2) MSI-GCs express the immune checkpoint molecules PD-L1 and PD-1 and

may

be considered suitable for the treatment with immune checkpoint inhibitors

in

the palliative setting

03/28/2017