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OMB Discussion on
Method Format &
Performance
Characteristics
(2-8-17)
Statistics
RSD
i
Definition
Acceptance Criteria
Guidance
Relationship ---> RSD
i
---> RSD
R
Relationship ---> RSD
i
---> RSD
r
LOD w/RSD
r
LOQ definition
PoD (currently in 4 different AOAC appendices)
LLA/MDL
Accuracy vs Recovery vs Mean Recovery
Measurement Uncertainty (MU)
PoD
False +/- Rate
False +/- Risk
PoD
How is RSD
R
assessed (other than Horrat)
Proficiency Testing
SMPR
Include RSD
i
in SMPR
Include RSD
i
in method
Inclusion of data in method
Interference/Inhibition
Org.
Harmonization
Guidance
(ISO/AFNOR/CODEX)
Micro
Accuracy
Reference method comparison
Validation & data assessment
What to do when no reference method is available
Pubs
Schedule
Next edition of OMA – Spring 2018
Retrofit SMPRs