463 / 923
Biopsies: at random - systematic
Chance of hitting tumor per biopsy=15-20%
Gleason score: poorly reproducible
Biopsy agreement with prostatectomy: (n=1670)
–
Gleason 5-6 undergrading: 35%
–
Gleason 8-10 overgrading: 35%
PSA
–
Suspected linear relation with amount of tumor cells
–
Irreliable due to leakage, often false positive
Conclusion: Literature contains probably higher Gleason scores too
Risk groups – Individual tumor characteristics: