The rate of intraprostatic relapses after primary EBRT is still not
negligible:
• 20-40% (20-25.000 failure/year)
• 60% - 72% of patients with negative metastatic workup and
rising PSA after RT will have positive prostatic biopsies
Zelefsky et al. Int. J. Radiat. Biol. Phys. 1998
Zagars et al. Int. J. Radiat. Biol. Phys. 1995
Pollack et al. Int. J. Radiat. Biol. Phys. 2002
Crook et al. Cancer. 1997
Alongi et al. CROH. 2013