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Stakeholder Panel on Agent Detection Assays
SPADA MEETING 15
03 FEB 2015
Matthew G. Davenport, Ph.D.
SPADA Ch i
1
a r
The Johns Hopkins University Applied Physics Laboratory
James Bradford
Executive Director
AOAC INTERNATIONAL
SPADA Objectives & History
Original Objectives in 2007
- Establish standards to validate Polymerase Chain Reaction (PCR)-based technologies that
detect aerosolized
Bacillus anthracis
,
Yersinia Pestis
, or
Francisella tularensis
- Pilot the validation process with an assay that detects
B. anthracis
2009
D l
d d
lid i
b d H d H ld A (HHA ) h d
-
eve op stan ar s to va ate mmunoassay- ase an - e ssays
s t at etect
B. anthracis
or Ricin in suspicious powders
- Test commercially-available HHAs
2010
- Develop standards to validate PCR-based technologies that detect aerosolized
Burkholderia psuedomallei
and
Burkholderia mallei
- Develop standards to validate PCR-based technologies that detect
B. anthracis
in
suspicious powders
2011
- Develop recommendations on controls needed for field-based assays
2013
2
- Develop standards to validate PCR-based technologies that detect aerosolized Variola
- Establish First Responder Working Group
- Maintain a SPADA Executive Steering Committee
2014
- Establish standards to validate technologies that detect Venezuelan Equine
Encephalitis Virus, Staphylococcus Entertoxin B, and
Coxiella burnetti
(Q-fever)