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TNM Staging of Head and Neck Cancer and Neck Dissection Classification
studied area. EGFR overexpression has been shown to be related to more
advanced tumor stage and nodal stage, as well as worse prognosis in terms of
locoregional control and overall survival. As a result, numerous compounds
are under investigation to evaluate their effect on progression of disease. The
most widely studied compound in the treatment of head and neck cancer is
cetuximab, a monoclonal antibody that inhibits the EGFR. The use of biologic
agents in head and neck cancer is an area of many ongoing research efforts.