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At the basis of each model there is a simple and intuitive formulation made by Fick:
Since the outflow from tissue to the venous system is of less clinical interest, it is
normally not investigated. It is relatively safe to assume BF
in
= BF
out
= BF
Perfusion Models Introduction
arterial
concentration
c
a
(t)
tissue
concentration
c
t
(t)
venous
concentration
c
v
(t)
BF
in
BF
out