191 / 1363
Contrast Agents
Gadolinium agents better
tolerated than iodinated (CT)
agents
Gd-DTPA (Magnevist) safety
record:
5 million uses, 1,234 AEs
(1992)
Anaphylactic shock and death
in 1 case
nephrogenic systemic fibrosis (NSF)
in kidney dysfunction
Macrocyclic agents (Dotarem, Prohance, Gadovist)
more commonly used IV
EMA recently suspended linear agents (Magnevist,
Optimark, Omniscan)