482-483 / 1363
•
Diffusion is not free / Gaussian distributed in biological tissues.
–
ADC value dependent on chosen b-values
•
Low b-values (< 150 s/mm
2
) probe for perfusion effects
•
Intermediate b-values (up to 1000 s/mm
2
, or 1/ADC) best for evaluating
diffusion metrics (ADC, FA, etc.)
Jones & Basser, 2004
•
Higher b-values (e.g., 2500 s/mm
2
) may be more beneficial for
tractography, likely as a result of greater sensitivity in detecting smaller
fibers
Rane, Nair & Duong, 2010
Summary: DWI contrast