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Contouring
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Segmentation may not result in useful tumor
definitions because of
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Noise
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Tracer uptake inhomogeneities (tumour+ backgr.)
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Sometimes low tumour-to-background ratios
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This also causes inter-method variability
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Segmented VOIs must be checked visually
+ Eur J Nucl Med Mol Imaging. 2011;38(12):2136–44