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Contouring

Segmentation may not result in useful tumor

definitions because of

Noise

Tracer uptake inhomogeneities (tumour+ backgr.)

Sometimes low tumour-to-background ratios

This also causes inter-method variability

Segmented VOIs must be checked visually

+ Eur J Nucl Med Mol Imaging. 2011;38(12):2136–44