Esophageal cancer:
Neo-adjuvant Chemoradiotherapy or Chemotherapy?
Stahl et al. J Clin Oncol 2009
N=126
T3-4 N0-1 M0
AC GEJ
Neo-adjuvant chemoradiotherapy:
PLF x2 + 30 Gy
+ Cisplatin 50 mg/m
2
d1,8 + etop 80 mg/m
2
d3-5
RESECTION
Primary endpoint: 3-year overall survival
R
A
N
D
O
M
Neo-adjuvant chemotherapy (PLF):
Cisplatin 50 mg/m
2
bi-wk + 5FU 2 g/m
2
wk x2.5
RESECTION
EBRO
2017