1057 / 1983
Definitive chemoradiotherapy
in locally advanced esophageal cancer
T1-T4,
N0-N1
M0
SCC
and AD
Primary endpoint: Survival
R
A
N
D
O
M
RTOG 94-05
EBRO
2017
Chemoradiotherapy (standard RT dose)
(50.4 Gy + cisplatin/5FU)
N= 109
higher radiation dose
does not improve outcome
Chemoradiotherapy (high RT dose)
(64.8 Gy + cisplatin/5FU)
N= 109
Minsky et al. J Clin Oncol 2002