1107 / 1983
EBRO
2017
Gastric cancer – adjuvant therapy
• Limited data
• No impact on survival, reduced local recurrence
• Historically over 30 (mostly small) randomised trials
• Meta-analyses suggest small benefit (HR 0.8)
• Recent positive studies:
• ACTS-GC trial (oral TS-1)
Sasako M
et al
(2011) J Clin Oncol 29:4387-4393
•
CLASSIC trial (capecitabine+oxaliplatin)
Bang YJ
et al
(2012) Lancet 379:315-321
• No benefit in small randomized trials in 1970-80s
• Gastric Surgical Adjuvant Trial INT 0116 (Macdonald
et al
2001)
Radiation therapy alone
Chemotherapy alone
Concurrent chemo-radiation therapy