1183 / 1983
Elective nodal (ENI) versus
involved-field irradiation (IFI)
N = 200
Elective nodal
(60-64 Gy)
Involved field
(68-74 Gy)
p
Local control @ 5yrs
node-only failure
IF failure
36 %
4 %
55 %
51 %
7 %
38 %
.03
.35
.02
Pneumonitis
29%
17% .04
OS @ 2 yrs
@ 5 yrs
26 %
18 %
39 %
25 %
.2
Inoperable stage III,
no PET
,
≤ 6 cm, SC -, pleura –
IK ≥ 80, weight loss < 10 %
4 – 6 cycles DDP-based CT concomitantly
Yuan AJCO 2007
Number To IFI
8 avoid 1 pneumonitis
9 to avoid 1 local failure @ 5 years