127 / 1983
PET/CT guided intensity-modulated radiotherapy
“dose painting”
– potential limitations
•
Chronically hypoxic cells have limited life-span.
•
Significant changes in oxygenation status after start of
radiotherapy.
•
Spatial resolution of PET-scanning and other imaging
modalities good enough for dose painting?
•
Significant dose escalation (>> 80 Gy) required for large
hypoxic subvolumes. May not be feasible.