1273 / 1983
PCI in extensive SCLC
PCI
N =143
Control
N = 143
HR NTT p
Symptomatic
brain mets
15 %
[8 – 21]
40 %
[32 – 49]
0.27
[0.16 – 0.44]
4 <0.0001
OS 1 yr
27 %
[19 – 36]
13 %
[8 – 20]
0.68
[0.59 – 0.88]
7 0.003
Extensive SCLC, 18 - 75 yrs., WHO 0 – 2, 2001 – 2006
Response to chemotherapy
Radiotherapy within 4 – 6 weeks after chemotherapy
20/8, 20/10, 24/12, 30/10, 30/12
Slotman NEJM 2007