14 / 1983
ESTRO: Evidence-based Radiation Oncology
• GR
ading of recommendations,
A
ssessment,
D
evelopment
and
E
valuations Working Group
• Systematic and explicit approach to preparing evidence-
based systematic reviews and clinical guidelines
GRADE
• Study limitations
Large magnitude of effect
• Inconsistency of results
Plausible biases would reduce effect
• Indirectness of evidence
Dose-response gradient
• Imprecision
• Publication bias
GRADE categorises the quality of the evidence
The GRADE approach
Guyatt British Medical Journal 2008