1413 / 1983
Randomization
345 pts
ARCON for T2-4 squamous cell carcinoma of the larynx
Accelerated Radiotherapy
Accelerated Radiotherapy
+
carbogen and nicotinamide
Fractionation schedule:
primary
metastatic nodes
Acc. RT
68 Gy
68 Gy
ARCON
64 Gy*
68 Gy
*Aim: improve tumor control with equal toxicity between arms!
174
171
Janssens et al. JCO 2012