148 / 1983
NCCTG 79-47-51 (1980-1986)
•
204 patients
•
Reduction in death highly significant for LAR (52%,
p
=
0.0037) but not significant for APR (10%,
p
= 0.92)
Krook JE et al. N Engl J Med. 1991;324(11):709-15
RT Chemo-RT
p value
5-year LR
63% 41% 0.0016
5-year OS
40% 55% 0.025
Late toxicity
6
7