1492 / 1983
Local Failure (LF) in BCT Subgroup
Hormonal therapy: Uni-variate analysis suggested
trend in reduction of LF with tamoxifen in BRCA2 carriers
BRCA1p=0.13
BRCA2p=0.08
Oophorectomy did not significantly impact LF*
BRCA1p=0.27
BRCA2p=0.125
*but 73% received chemotherapy;
only 16% received no adjuvant therapy.
Pierce et al. BCRT, 2010