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Baseline Characteristics (

Whelan et al, NEJM 2015)

WBI

N=916

WBI+RNI

N=916

Age

(mean)

53

54

Axillary nodes removed

(mean)

12

12

Node Negative

10%

10%

Node Positive (1-3)

85%

85%

Tumor size > 2cm

45%

50%

Grade III

42%

43%

ER Negative

26%

25%

Adjuvant chemotherapy

91%

91%

Adjuvant endocrine therapy

77%

77%

Boost irradiation

35%

32%

Median follow-up of 62 months