1742 / 1983
Randomized Trial of IMRT vs. Standard
RT in early breast cancer
• 306 patients
• 50 Gy/25 fractions ± boost 11 Gy/5
Standard
IMRT
p
> 20% of breast
>105% of dose
15%
1%
0.005
Worsen in breast
appearance
58%
40%
0.008
Central breast
fibrosis
32%
21%
0.02
Donovan et al.
Radiother Oncol,
2007