1894-1895 / 1983
Palliative RT lung dose & fractionation
•
Poor PS:
•
1 fraction (10Gy) as good as 2 fraction (17Gy/ 2#; 1 week apart)
•
PS 2 – 4; Main symptoms from primary
•
Max 200 cm
2
field
•
Median OS 3.5 vs 4 months
•
Better PS:
•
13 fraction (39Gy/ 13#) vs. 2 fraction (17Gy/ 2#)
•
Locally advanced, non-metastatic
•
7 vs. 9 months OS
Bleehan, BJC, 1992
Macbeth, ClinOnc1996