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Risk-stratified treatment (pre-op)

Early (‘

Good

’)

surgery alone sufficient

Intermediate (‘

Bad

’)

give pre-op RT (5 × 5 Gy)

or

CRT

Locally advanced (‘

Ugly

’)

CRT needed to achieve high probability of R0 surgery

Glimelius B. Ann Oncol. 2010;21 Suppl 5:v82-6.