Risk-stratified treatment (pre-op)
•
Early (‘
Good
’)
–
surgery alone sufficient
•
Intermediate (‘
Bad
’)
–
give pre-op RT (5 × 5 Gy)
or
CRT
•
Locally advanced (‘
Ugly
’)
–
CRT needed to achieve high probability of R0 surgery
Glimelius B. Ann Oncol. 2010;21 Suppl 5:v82-6.