329 / 1983
Early stage disease
•
Level Ib evidence
•
Randomised study of radical surgery versus radiotherapy
for stage Ib-IIa cervical cancer
–
469 women
–
Post-op RT if pT2b or greater, <3 mm uninvolved
cervical stroma, involved margin, positive nodes
•
Results
–
No difference in OS (84% both groups)
–
More morbidity with surgery (28% vs.12%,
p
= 0·0004)
Landoni F, et al. Lancet. 1997;350(9077):535-40.