510-511 / 1983
Case 1
•
Benefits of surgery:
•
No randomised data on the benefit of surgery in newly diagnosed GBM in most
patients
*
•
Repeated data from retrospective analysis of trial patients
•
Trials of surgical adjuvants (IO-MRI, 5-ALA)
•
Often group patients by extent of resection (GTR; STR; Bx)
•
Consistent message:
•
GTR >
OS
STR/Bx; GTR >
6mPFS
STR/Bx
•
Less clear (but perhaps true):
•
GTR >
OS
STR >
OS
Bx; GTR >
6mPFS
STR >
6mPFS
Bx
•
However, these are all post-hoc analyses
•
What is the obvious confounding factor here ?
*
Vuorinen et al.
Acta Neuro. 2003