54 / 1983
Ioannidis PLOS Med 2005
• Lack of power
•
small studies / small effects
•
repeated tests
• Bias (≠ chance variability)
•
patient selection
•
flexibility (design, outcome, analysis)
•
selective reporting / reading
|
|
54 / 1983
Ioannidis PLOS Med 2005
• Lack of power
•
small studies / small effects
•
repeated tests
• Bias (≠ chance variability)
•
patient selection
•
flexibility (design, outcome, analysis)
•
selective reporting / reading