918 / 1983
Tra
Is the adoption of BRT as boost
evidence – based? Data from RCTs
The adoption of BRT as boost
could be considered evidence based
Author
(year)
Years of
enrollement
PTS BRT schedule
EBRT dose Risk
group
FUP
(years)
5-y
bRFS
(%)
Santhia
(2005)
1992-1997 51
53
-
35 Gy (HDR)
66
40
IR
HR
8.2
49
71
p = 0.04
Hoskin
(2012)
1997-2005 108
110
-
17 X 2 (HDR)
55 (2.75)
35.75
(2.75)
LR
IR
HR
12
61
75
p = 0.002
RTOG
0232
2003 - 2012 296
292
LDR
EBRT + LDR
125-145
45 + 125/145
IR 5
NS