207_Combined course Presentations

Small Cell Lung Cancer (SCLC)

 Reduced incidence (from 25-30 to 13-15%)

 Strongly associated with cigarette smoking

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Neuroendocrine features

 High frequency of TP53 and RB gene mutations

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Highly responsive to CT and RT

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High rate of early relapse/PD

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Highly aggressive

 Often metastasized at the time of diagnosis

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Poor cure-rate (10-20%) and overall

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prognosis (MS 9-12 months)