207_Combined course Presentations

Neuroendocrine tumors of the lung

Carcinoid

Atypical Carcinoid

LCNEC SCLC

Mitoses/2mm 2 (10 HPF)

<2

2-10

>10

>10

Smoking

33% (general population)

64%

98%

97%

5 YR OS

92-100%

61-88%

13-57%

5%

Prevalence

1-2%

0.1-0.2% 1.6-3% 15%

TP53 mutation

6%

-

74%

90%

RB1 down-regulation

0%

21%

68%

87%

MEN mutation

18%

36%

0%

0%

Beasley et al. Human Pathol , 2003 Haruki et al. Jpn J can cer Res, 2000 Adapted from Swarts et al. BBA-Rev on Cancer ,2012