207_Combined course Presentations

Oncogene Addiction: 2 models

b) oncogenic shock model

In the ‘oncogenic shock’ model, addictive oncoproteins (e.g. RTKs, red triangle) trigger at the same time pro- survival and pro-apoptotic signals (top, red and blue pathway, respectively). Under normal conditions, the pro- survival outputs dominate over the pro-apoptotic ones (top), but following blockade of the addictive receptor , the rapid decline in the activity of survival pathways (dashed lines, bottom) subverts this balance in favour of death-inducing signals, which tend to last longer and eventually lead to apoptotic death.