207_Combined course Presentations

Ionizing Radiation (IR) induces the secretion of multiple ADAM substrates in vitro and in vivo

Amphiregulin Betacellulin ALCAM

(A549 adenocarcinoma cells)

Upstream Mechanism: ADAM17

Negative Control

VEGFA

Normoxia

uPA

Hypoxia

Ionizing Radiation

(In parallel: Screening of patient serum as part of clinical trials)

Sharma A et al . Clin. Cancer Research (2016)