207_Combined course Presentations

ADAM17 (A Disintegrin and Metalloprotease 17) - Signaling Scissors

Tumour Biol. 2013 Jun;34(3):1813-8.

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=370

 ADAM 17 also called TACE (tumor necrosis factor-α-converting enzyme)  Present at the trans-Golgi-network and plasma membrane

 ADAM17 is overexpressed in NSCLC and correlates with poor patient survival