207_Combined course Presentations

Stupp Regimen: major benefit seen in methylated patients

 Patients with GBM containing a methylated MGMT promoter benefited from TMZ

 Unmethylated patients did not have such a benefit; for these patients alternative treatments with different mechanisms of action or methods of inhibiting MGMT shoulf be investigated

• Can we “somehow” overcome TMZ resistance…?

Hegi M. et al. NEJM 2005;352