207_Combined course Presentations

Alternative TMZ post-radiation dosing regimens

Regimen

Dose and schedule

Drug exposure

150-200mg/m 2 x 5d q28d

Standard monthly

1

50mg/m 2 /d

Continuous daily

1.8

75mg/m 2 /d x 7d/wk for 6 wk

Continuous (42-49/56-63)

2.1

85-100 mg/m 2 /d x 21d q 28d

Alternating (21/28)

2.6

135-150 mg/m 2 /d x 7d qow

Alternating weekly (7/14)

3.2

200 mg/m 2 (1 st dose), 90-100 mg/m 2 q12h x 9 doses

Twice daily

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