207_Combined course Presentations

Alternative regimens: Alternating TMZ

A MGMT activity in PBMC after treatment with temozolomide 7 days on/7days off schedule

B MGMT activity in PBMC after treatment with temozolomide 21/28 day schedule

Average decrease in MGMT activity

Dose and schedule

DAY 7

DAY 14-15

DAY 21

50 to 175 mg/m 2 /day x 7 days every other week

72%

55%*

50 to 150 mg/m 2 /day x 21 days with 1 week rest

63%

73%

*After 7-day treatment free period

Tolcher AW. et al. Br J Cancer 2003;88