Physics Bucharest 2017

2 nd tumors in patients treated for BREAST CANCER

Exces cancer risk due to radiotherapy Close to irradiated tumor

INCIDENCE

ERR

2p

contralateral breast cancer

18% 0,002 61% 0,0007 106% 0,05 71% 0,04 134% 0,03

lung cancer

oesophagus cancer

leukemia

soft-tissue carcinoma

Clinical data: breast cancer

Lancet 2005; 366: 2087–2106

• meta analysis of 78 randomized trials • 32.800 patients in studies evaluating addition of RT (50% irradiated)

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