Physics Bucharest 2017

2 nd tumors in patients treated for BREAST CANCER

Second tumor: contralateral breast cancer (CBC)

 40-50% of all secondary tumors are in the contralateral breast.  At 15y, 10-13% of patients have developed contralateral tumor (2- to 5-fold higher than general female population).  High risk for CBC is mostly unrelated to RT ( pre-disposition ).  Conflicting data on contribution of RT: Some large studies show increased risk for CBC due to RT, others only for young patients, others don’t show any enhanced risk  Hormonal treatment with tamoxifen reduces risk for CBC by 30-40%

Clinical data: breast cancer

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