CROI 2015 Program and Abstracts

Abstract Listing

Poster Abstracts

Poster Abstracts

Figure 1. Phylogenetic Tree Constructed Based on the Partial Segment of the NS5B Region. Reference recombinant strains RF 2k/1b in shown red diamond, genotype 1 in green, genotype 3 in purple and 2 in blue. Reference sequences are shown by their isolate name and country. Numbers at the nodes show the percentages of bootstrap values. Conclusions: Since 21 specimens were considered genotype 2 based on standard HCV genotyping methods; there is a need for genotyping in two genomic regions at least for genotype 2. The high prevalence of possible RF2k/1b in our small sample group stresses the need of further studies, as this formmight circulate in Georgia widely and may alter treatment options and/or duration as it shares non-structural regions with genotype 1 and may be as difficult to treat as this genotype 665 High HCV Prevalence Among Baby Boomers in Surveillance-Identified High HIV Risk Areas Irene Kuo 1 ; MeriamMikre 1 ; A.ToniYoung 2 ; Geoffrey Maugham 2 ; Amanda D. Castel 1 1 George Washington University, Washington, DC, US; 2 Community Education Group, Washington, DC, US Background: Despite advances in HCV screening, treatment, and recommendations, approaches for conducting HCV screening among baby boomers have not been fully explored. Because of the lack of hepatitis surveillance data and given shared risk factors for HIV and HCV, we used a novel method of identifying high HIV risk census tracts (CTs) using HIV surveillance data to target community-based HCV testing. We conducted a pilot study to estimate HCV seroprevalence and identify new and out of care HCV-seropositive baby boomers in these areas. Methods: Between August-September 2014, we conducted community-based HCV rapid testing (OraQuick Rapid HCV Antibody Test) in Washington, DC in high risk CTs identified using an algorithm utilizing routinely reported HIV surveillance data incorporating HIV prevalence and suboptimal HIV care continuum outcomes (e.g., high community viral load and proportions of persons never in/out of HIV care). HCV testing was done by street outreach in the 12 highest ranking CTs. Eligible participants were born between 1945-1965 and not currently engaged in HCV care. Confidential testing and a face-to-face behavioral survey were conducted in a mobile unit or at a local community-based organization office. HCV antibody (HCVAb)-positive individuals were asked to provide a blood specimen for confirmation and referred to HCV care. Confirmatory testing is ongoing, and seropositive participants will be followed prospectively for 3 months to assess linkage to care. We report seroprevalence and baseline behavioral data using frequencies, chi-square and t-tests. Results: Of 197 participants, 94%were black, mean age was 55 (SD ± 5), 74%were male, and 73% had public health insurance (see Table). 30% had ever injected drugs, 14% had ever been incarcerated, and 24% had ever been tattooed. 76% had never tested for HCV before. Overall, 59 (30%) were HCVAb-positive. 30% knew their HCV status but were not

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CROI 2015