AOAC SPIFAN Stakeholder Panel Meeting Book (March 12, 2020)

Vitamin A AOAC 2011.07 Method Performance

Vitamin E Introduction and Background

Vitamin E – a group of eight fat soluble compounds (four tocopherols and four tocotrienols) which function as antioxidants There are 3 chiral centers in the tocopherols which results in 8 potential isomers for each of the 4 tocopherols. In infants, vitamin E supplementation may reduce the risks of severe retinopathy, intracranial hemorrhage, hemolytic anemia, chronic lung disease, decreased immune function Vitamin E may have specific roles in neurodevelopment and cognition. Tocopherol Transfer Protein is specific for d -a-tocopherol Current Food and Drug Administration (FDA)-approved levels of adequacy and of upper limits in infant formulas for vitamin E are 0.5 and 5 TE per 100 kcal but should contain no less than 0.5 mg TE/g a-linoleic acid equivalent. Infant formula should contain 0.5–5 mg a-TE/100 kcal (a-tocopherol equivalent, 1 mg a-TE = 1 mg d-a-tocopherol), but not less than 0.5 mg/g linoleic acid or equivalent (0.5 mg a-TE/g linoleic acid (18:2n-6); 0.75 mg a-TE/g a-linolenic acid (18:3n-3); 1.0 mg a-TE/g arachidonic acid (20:4n-6); 1.25 mg a-TE/g eicosapentaenoic acid (20:5n-3); 1.5 mg a-TE/g docosahexaenoic acid (22:6n-3).