Research Masterclass in Radiotherapy Physics 2017

Dependence of RBE and OER on LET

He: ▲ , 12 C: ● , 20 Ne: ▼

C

O

p

C

Weyrather Int. J. Rad. Biol. (1999),

Furusawa Rad. Res. (2000)

• Increased RBE for high LET in resistant tumors. • Improved outcome for high LET in hypoxic tumors. • Benefit for Carbon as compared to protons

The clinical relevance of has not been shown yet.

Oliver Jäkel

Medical Physics

Page 9

Proton RT for Medulloblastoma treatments

Stokkevåg et al. Acta Oncol 2014

Finite range of protons reduces dose to dose reduction in heart, lung, intestine, mediastinum

Oliver Jäkel

Medical Physics

Page 10