The Cleveland Clinic. Pediatría, Sabella, Camille

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Capítulo 33: Epilepsia y terapia anticonvulsiva

9.  Los efectos adversos del topiramato son (más de una res- puesta puede ser correcta): a)  Dificultades cognitivas. b)  Nefrolitiasis. c )  Insuficiencia hepática. d)  Molestias gastrointestinales. Respuesta La respuesta es a) y b). 10.  ¿Con cuál de las combinaciones que siguen puede ob- servarse interacción importante entre antiepilépticos? a)  Levetiracetam y carbamazepina. b)  Gabapentina y fenobarbital. c )  Valproato y lamotrigina. d)  Felbamato y oxcarbazepina. Respuesta La respuesta es c). LECTURAS RECOMENDADAS Abdul M, Riviello JJ. Update on the newer antiepileptic drugs in child neurology: advances in treatment of pediatric epilepsy. Curr Treat Options Neurol 2007;9(6):395–403. Azar NL, Abou-Khalil BW. Considerations in the choice of an antiepi- leptic drug in the treatment of epilepsy. Semin Neurol 2008; 28(3):305–316. Baulac S, Gourfinkel-An I, Nabbout R, et al. Fever, genes, and epilepsy. Lancet Neurol 2004;3(7):421–430. Bourgeois B. New antiepileptic drug in children: which ones for which seizures? Clin Neuropharmacol 2000;23:119–132. Camfield PR, Camfield CS, Shapiro SH, et al. The first febrile seizu- re-antipyretic instruction plus either phenobarbital or placebo to prevent recurrence. J Pediatr 1980;97(1):16–21. Chiron C, Marchand MC, Tran A, et al. Stiripentol in severe myoclonic epilepsy in infancy: a randomised placebo-controlled syndrome-dedi- cated trial. STICLO study group. Lancet 2000;356(9242):1638–1642. doi:10.1016/S0140-6736(00)03157-3. Commission on Classification and Terminology of the International League Against Epilepsy. Proposal for classification of epilepsies and epileptic syndromes. Epilepsia 1985;26:268. Ellenberg JH, Nelson KB. Febrile seizures and later intellectual perfor- mance. Arch Neurol 1978;35(1):17–21. Farwell JR, Lee YJ, Hirtz DG, et al. Phenobarbital for febrile seizures: effects on intelligence and on seizure recurrence. N Engl J Med 1990; 322(6):364–369. Frank LM, Shinnar S, Hesdorffer DC, et al. Cerebrospinal fluid fin- dings in children with fever-associated status epilepticus: results of the consequences of prolonged febrile seizures (FEBSTAT) study. J Pediatr 2012;161(6):1169–1171. doi:10.1016/j.jpeds. 2012.08. 008. Gerard F, Pereira S, Robaglia-Schlupp A, et al. Clinical and genetic analy- sis of a new multigenerational pedigree with GEFS + (Generalized Epilepsy with Febrile Seizures Plus). Epilepsia 2002;43:581–586. Glaze DG, Hrachovy RA, Frost JD Jr, et al. Prospective study of outcome of infants with infantile spasms treated during controlled studies of ACTH and prednisone. J Pediatr 1988;112:389–396. Hesdorffer DC, Benn EK, Bagiella E, et al. Distribution of febrile sei- zure duration and associations with development. Ann Neurol 2011; 70(1):93–100. doi:10.1002/ana.22368.

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