SPSFAM Heavy Metals ERP Book

AOAC Expert Review Panel for Heavy Metals 

ER 4 in Section E, all CAS numbers and their purities were mentioned on solid materials (they have  included Source of supply and Catalog number for ease of use), for reference materials in liquid  forms, the traceability to NIST was mentioned. The standard reference material 1643e was also  used. this section did not include NIST 1640  which was used in multilibrary validation but since  the method is applicable without this SRM and  it is not necessary to be added to this section.   Section E. The reference material and chemical standards were given by the authors. SRM  1640a and SRM  1643e were listed for standard reference materials. ER 7 Certified Reference Materials for arsenic species in fruit juice were not available at the time of  the study. NIST SRM 1643e Trace Elements in Water, which is certified for total arsenic  concentration at 58.98 ± 0.70 µg/kg, was analyzed by seven laboratories. In addition, two  laboratories analyzed NIST SRM 1640a Trace Elements in Natural Water, which is certified for  total arsenic concentration at 8.010 ± 0.067 µg/kg. Each laboratory analyzed a minimum of one  preparation of SRM with each batch of samples analyzed. (C onklin et al .: J ournal of aoaC i  nternational V ol . 99, n o . 4, 2016 1125 ER 8 Section E(g) What type of single laboratory validations were used for this method [i.e, Harmonized PTM,  Precollaborative, Independent, Collaborative, etc.] and where is it referenced in the method  documentation? ER 5 ER 6 Not considered ER 2 The single lab validation was published. It was Independent. The method was validated by  reference material analyses, recovery of analytes and precision measurements.  ER 3 Assessment of SLV to SMPR were included in report from author. ER 4 LOQ, Precision and recovery are meeting the SMPR minimum acceptance criteria with LOQ of 2  ppb RTD Juices and 12 ppb for Concentrate Juices. (SMPR  ER 5 As noted by previous reviewers for the First Action Method, the linearity of the method was not  discussed.  The First Action Method was based on the USFDA method in the EAM (Elemental  Analysis Manual).   ER 6 Collaborative study ER 7 The method was validated by reference material analyses, recovery of analyte, and precision  measurements (8). Juices used in method validation included red grape, purple grape, white  grape, apple, pear, cranberry, cherry (juice blend), and berry (juice blend). The precision of  analyses for the three analytical portions was ≤10% RSD for species present at concentrations  ≥LOQ. Recovery of the added analyte was in the range of 80–120% for all four species in all  juices tested. As results for NIST SRM 1640 Trace Elements in Natural Water agreed with the  certificate value for total arsenic, differing by  ER 8 Section M, independent collaborative 2 laboratories ER 1 Independent SLV. 8  juices used. RSDr for n=3 was 

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