Dose Course 2018_Flipping book

Action limits - Proposed philosophy

Step 4:

Define the center of the true dose probability distribution as the lower and upper action limit , respectively.

Prescribed dose

Probability distribution for the true dose

Dose (Gy)

is set to a minimum acceptable cure rate

TL

is set to a maximum acceptable complication rate

TL

−D

D

+

Clinical tolerance limits